Enantioselective syntheses of (+)- and (-)-blastmycinolactol

被引：19

作者：

Jacobi, PA

Herradura, P

机构：

[1] Hall-Atwater Laboratories, Wesleyan University, Middletown

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 38期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)01533-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(-)-Blastmycinolactol (1b) has been prepared in an enantioselective fashion from acetylenic acid 5 by a three step sequence involving debenzylation-lactonization, hydration with concurrent C-3-epimerization, and Baeyer-Villiger oxidation accompanied by ester cleavage. Acylation of 1b with isovaleryl chloride then afforded (+)-blastmycinone (1a) in excellent overall yield. (C) 1997 Elsevier Science Ltd.

引用

页码：6621 / 6624

页数：4

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