Maintenance of intestinal epithelium structural integrity and mucosal leukocytes during chemotherapy by oral administration of muramyl tripeptide phosphatidylethanolamine

被引：5

作者：

Killion, JJ ^{[1
]}

Bucana, CD ^{[1
]}

Radinsky, R ^{[1
]}

Dong, ZY ^{[1
]}

OReilly, T ^{[1
]}

Bilbe, G ^{[1
]}

Tarcsay, L ^{[1
]}

Fidler, IJ ^{[1
]}

机构：

[1] CIBA GEIGY LTD,CH-4002 BASEL,SWITZERLAND

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 1996年 / 11卷 / 06期

关键词：

MTP-PE; chemotherapy; intestinal epithelium;

D O I：

10.1089/cbr.1996.11.363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The systemic administration of doxorubicin (DXR) decreases the number of epithelial cells and leukocytes in the small intestine of mice. Oral administration of muramyl tripeptide phosphatidylethnnolamine (MTP-PE) prevented both disruption of intestinal architecture, and a decrease in the number of macrophages, and it induced the expression of lL-6, G-CSF, GM-CSF, and TNF-alpha in the intestinal tissue. The data suggest that the oral administration of MTP-PE can prevent chemotherapy-induced toxicity to the intestinal mucosa and hence infections due to translocation of aerobic bacteria from the intestine to the blood.

引用

页码：363 / 371

页数：9

共 41 条

[1] LIPOSOME-ENCAPSULATED MURAMYL TRIPEPTIDE UP-REGULATES MONOCYTE CHEMOTACTIC AND ACTIVATING FACTOR GENE-EXPRESSION IN HUMAN MONOCYTES AT THE TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL LEVELS [J].