Convenient and Efficient Preparations of Azodye-Labeled Peptides

被引：15

作者：

Katritzky, Alan R. ^{[1
]}

Chen, Qi-Yin ^{[1
]}

Tala, Srinivasa R. ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2009年 / 73卷 / 06期

关键词：

azodye; benzotriazole methodology; N-protected(alpha-aminoacyl)benzotriazole; photoisomerization; small peptides; AMINO-ACIDS; PHOTOBIOLOGICAL SWITCHES; ALPHA-CHYMOTRYPSIN; MOLECULAR BEACONS; TEMPORARY MARKER; BINDING; PHOTOREGULATION; REAGENTS; ASSAY;

D O I：

10.1111/j.1747-0285.2009.00813.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-(4-Arylazobenzoyl)-1H-benzotriazoles 15a, 15b react with dipeptides 12a-d, (12d+12d') and tripeptides 14a, 14b to give azodye labeled-dipeptides (16a-e), (16d+16d'), (16e+16e') and -tripeptides 16f, 16g in high yields (73-93%) with retention of chirality.

引用

页码：611 / 617

页数：7

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