Neurogenic factors and hypertension in renal disease

被引:59
作者
Campese, VM [1 ]
机构
[1] Univ So Calif, Los Angeles Cty Med Ctr, Div Nephrol, Dept Med, Los Angeles, CA 90033 USA
关键词
chronic renal failure; hypertension; sympathetic nervous system; nitric oxide;
D O I
10.1046/j.1523-1755.2000.07511.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Hypertension in chronic renal failure (CRF) is very common and contributes to morbidity and mortality and to the progression of renal disease. The pathogenesis of hypertension in CRF has been attributed mostly to sodium retention and to activation of the renin-angiotensin-aldosterone system. More recently an abundance of evidence has accumulated to support a role for increased sympathetic nervous system (SNS) activity in the genesis of hypertension associated with CRF. Evidence from our laboratory has also demonstrated that the rise in central SNS activity is mitigated by increased local expression of nitric oxide synthase (NOS)-mRNA and nitric oxide (NO) production, and that the upregulation of NO production in the brain is mediated by IL-1 beta.
引用
收藏
页码:S2 / S6
页数:5
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