Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-α-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts

被引：34

作者：

Andoh, A ^{[1
]}

Shimada, M ^{[1
]}

Bamba, S ^{[1
]}

Okuno, T ^{[1
]}

Araki, Y ^{[1
]}

Fujiyama, Y ^{[1
]}

Bamba, T ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Internal Med, Otsu, Shiga 5202192, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2002年 / 1591卷 / 1-3期

关键词：

extracellular signal-regulated kinase; interleukin; myofibroblast;

D O I：

10.1016/S0167-4889(02)00250-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha-induced IL-6 secretion through the induction of IL-6 mRNA stabilization. Induced stability of IL-6 mRNA was markedly decreased by the inhibitors of extracellular signal-regulated kinase (ERKs), PD98059 and U0216. This indicates that activation of the ERK pathway is involved in the induction of IL-6 mRNA stabilization by IL-17 plus TNF-alpha. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：69 / 74

页数：6

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