Getting newly synthesized proteins into shape

被引：345

作者：

Bukau, B

Deuerling, E

Pfund, C

Craig, EA

机构：

[1] Univ Wisconsin, Dept Biomol Chem, Madison, WI 53706 USA

[2] Univ Freiburg, Inst Biochem & Mol Biol, D-79104 Freiburg, Germany

来源：

CELL | 2000年 / 101卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(00)80806-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent progress made in the analysis of in vivo folding of cytosolic proteins suggests that folding of cytosolic proteins occurs via multiple chaperone-assisted, as well as unassisted pathways. In the case of individual proteins, certain pathways may be highly favored. But, the cellular folding machinery also shows significant redundancy and flexibility, resulting in a variable network of folding pathways having alternative routes and backup systems.

引用

收藏

页码：119 / 122

页数：4

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