Cobalt-55 positron emission tomography in ischemic stroke

After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Go) as a Ga-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Go-PET may have prognostic value in stroke. Six stroke patients were examined with Go-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient? specific Go-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Go-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary. (C) 1997 Elsevier Science B.V.