共 18 条
Do women benefit more from systemic thrombolysis in acute ischemic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) study
被引:31
作者:

Jovanovic, D. R.
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机构:
Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia

Beslac-Bumbasirevic, Lj.
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h-index: 0
机构:
Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia

Budimkic, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia

Pekmezovic, T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Belgrade, Sch Med, Inst Epidemiol, Belgrade 11001, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia

Zivkovic, M.
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h-index: 0
机构:
Clin Ctr Nis, Dept Neurol, Nish, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia

Kostic, V. S.
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h-index: 0
机构:
Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia
机构:
[1] Clin Ctr Serbia, Sch Med, Inst Neurol, Belgrade 11000, Serbia
[2] Univ Belgrade, Sch Med, Inst Epidemiol, Belgrade 11001, Serbia
[3] Clin Ctr Nis, Dept Neurol, Nish, Serbia
关键词:
Stroke;
Acute;
Women;
Thrombolysis;
Outcome;
TISSUE-PLASMINOGEN ACTIVATOR;
SEX-BASED DIFFERENCES;
OUTCOMES;
GENDER;
TRIAL;
CLASSIFICATION;
FIBRINOLYSIS;
ASPIRIN;
D O I:
10.1016/j.clineuro.2009.06.014
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objective: The female sex is associated with increased stroke severity and relatively poor functional recovery. Several studies have demonstrated that women with stroke benefit more from intravenous thrombolysis compared with men, while others found the nullification of gender effect among women treated with recombinant tissue plasminogen activator (rtPA). The purpose of our study was to determine any gender differences in the efficacy and safety of systemic thrombolysis among patients with acute ischemic stroke in Serbia. Methods: Data were from the Serbian experience with intravenous thrombolysis in ischemic stroke (SETIS) study, a prospective, ongoing, multicenter, open, and observational study in Serbia of all patients who have received rtPA for acute ischemic stroke. We analyzed sex differences in the baseline characteristics, functional outcome and treatment complications. Results: Among 60 women and 96 men with stroke and treated with intravenous thrombolysis, we found that at day 90, no significant sex differences in excellent functional outcome (50.9% of women vs. 57.0% of men, p = 0.5), favorable functional outcome (61.4% of women vs. 68.8% of men, p = 0.38) or death (8.8% of women vs. 12.9% of men, p = 0.60). These results were constant even after adjustments for age, severity of basal neurological deficit and onset to treatment time. Conclusion: There were no sex differences in functional outcome at 90 days after the stroke among patients treated with IV rtPA. This finding might confirm that thrombolytic therapy nullifies usual sex differences in stroke outcome and suggests that women with stroke may benefit more from rtPA treatment. (C) 2009 Elsevier B.V. All rights reserved.
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页码:729 / 732
页数:4
相关论文
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Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England

Grant, PJ
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机构:
Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England

Catto, AJ
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机构:
Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England Univ Leeds, Gen Infirm, Acad Unit Mol Vasc Med, Leeds LS1 3EX, W Yorkshire, England
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The gender effect in stroke thrombolysis - Of CASES, controls, and treatment-effect modification
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Kent, David M.
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机构:
Tufts Univ, Sch Med, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies,Ctr Cardiovas, Boston, MA 02111 USA Tufts Univ, Sch Med, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies,Ctr Cardiovas, Boston, MA 02111 USA

Buchan, Alastair M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Oxford OX1 2JD, England Tufts Univ, Sch Med, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies,Ctr Cardiovas, Boston, MA 02111 USA

Hill, Michael D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calgary, Foothills Hosp, Dept Clin Neurosci, Calgary Stroke Program, Calgary, AB T2N 1N4, Canada Tufts Univ, Sch Med, Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies,Ctr Cardiovas, Boston, MA 02111 USA
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Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke - A pooled analysis of randomized clinical trials
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STROKE,
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Kent, DM
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h-index: 0
机构: Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA

Price, LL
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机构: Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA

Ringleb, P
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h-index: 0
机构: Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA

Hill, MD
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h-index: 0
机构: Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA

Selker, HP
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机构: Tufts Univ, New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA