Nitric oxide induces cultured cortical neuron apoptosis

被引：76

作者：

Palluy, O

Rigaud, M

机构：

[1] URA-CNRS 1485, Fac. de Med. et de Pharm. de Limoges, 87025 Limoges, 2, rue du Docteur Marcland

来源：

NEUROSCIENCE LETTERS | 1996年 / 208卷 / 01期

关键词：

nitric oxide; neurons; apoptosis; DNA fragmentation; chromatine condensation;

D O I：

10.1016/0304-3940(96)12532-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A series of experiments were designed to examine the potential induction of apoptosis by nitric oxide (NO) donors on cortical neuronal cell culture. A 24 h exposure of three different NO donors, 3-morpholinosydnonimine, S-nitroso-N-acetyl-penicillamine, and S-nitrosoglutathione, induced apoptosis as indicated by following histological (cellular and nuclear morphology) and biochemical markers (DNA oligonucleosomal fragmentation and protection by protein synthesis inhibitor).

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页码：1 / 4

页数：4

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