Spontaneous axonal regeneration after optic nerve injury in adult rat

被引:44
作者
Campbell, G [1 ]
Holt, JKL [1 ]
Shotton, HR [1 ]
Anderson, PN [1 ]
Bavetta, S [1 ]
Lieberman, AR [1 ]
机构
[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England
关键词
axon sprouting; CNS regeneration; lesion site; optic nerve; optic nerve crush;
D O I
10.1097/00001756-199912160-00042
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
OPTIC nerves of adult rats were crushed 2 mm behind the eye to examine the ability of retinal ganglion cells (RGCs) to regenerate their axons. Some animals were treated with the immunophilin ligands FK 506 or GPI 1046 for up to 4 weeks. After 10 days to 16 months, regenerating RGC axons were visualized using anterograde tracing and/or electron microscopy. A small proportion of RGC axons regenerated across the lesion site and grew very slowly along the entire optic nerve. Immunophilin ligands had no obvious effect. The regenerating axons were about 0.2 mu m in diameter, and usually in clusters surrounded by astrocyte processes. Thus, some CNS axons can spontaneously regenerate long distances within degenerate white matter and this slow regeneration is not accelerated by immunophilin ligands. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:3955 / 3960
页数:6
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