Regulation of the aging process by autophagy

被引:235
作者
Salminen, Antero [1 ,2 ]
Kaarniranta, Kai [3 ,4 ]
机构
[1] Univ Kuopio, Inst Clin Med, Dept Neurol, FIN-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland
[3] Univ Kuopio, Inst Clin Med, Dept Ophthalmol, FIN-70211 Kuopio, Finland
[4] Kuopio Univ Hosp, Dept Ophthalmol, FIN-70211 Kuopio, Finland
基金
芬兰科学院;
关键词
CHAPERONE-MEDIATED AUTOPHAGY; NF-KAPPA-B; FOXO TRANSCRIPTION FACTORS; LIFE-SPAN EXTENSION; C-ELEGANS; CAENORHABDITIS-ELEGANS; CALORIE RESTRICTION; OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; DIETARY RESTRICTION;
D O I
10.1016/j.molmed.2009.03.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autophagy is involved in cellular protein and organelle degradation, which is mediated by the lysosomal pathway. Autophagocytosis has a key role in cellular housekeeping by removing damaged organelles. During aging, the efficiency of autophagic degradation declines and intracellular waste products accumulate. In Caenorhabditis elegans, there is clear evidence that lifespan is linked to the capacity to regulate autophagy. Recent studies have revealed that the same signaling factors regulate both aging and autophagocytosis, thus highlighting the role of autophagy in the regulation of aging and age-related degenerative diseases. Here, we examine in detail the interactions of the signaling network involving longevity factors SIRT1, mTOR, FoxO3, NF-kappa B and p53 in the regulation of autophagy. We discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via autophagy.
引用
收藏
页码:217 / 224
页数:8
相关论文
共 95 条
[1]   Thinking globally and acting locally with TOR [J].
Arsham, Andrew M. ;
Neufeld, Thomas P. .
CURRENT OPINION IN CELL BIOLOGY, 2006, 18 (06) :589-597
[2]  
ARSTILA AU, 1969, VIRCHOWS ARCH B, V2, P85
[3]   The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane [J].
Bandyopadhyay, Urmi ;
Kaushik, Susmita ;
Varticovski, Lyuba ;
Cuervo, Ana Maria .
MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (18) :5747-5763
[4]   The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically [J].
Bergamini, E ;
Cavallini, G ;
Donati, A ;
Gori, Z .
BIOMEDICINE & PHARMACOTHERAPY, 2003, 57 (5-6) :203-208
[5]   The role of autophagy in aging - Its essential part in the anti-aging mechanism of caloric restriction [J].
Bergamini, Ettore ;
Cavallini, Gabriella ;
Donati, Alessio ;
Gori, Zina .
HEALTHY AGING AND LONGEVITY, 2007, 1114 :69-78
[6]  
Bergamini Ettore, 2006, Molecular Aspects of Medicine, V27, P403, DOI 10.1016/j.mam.2006.08.001
[7]   Genetic links between diet and lifespan: shared mechanisms from yeast to humans [J].
Bishop, Nicholas A. ;
Guarente, Leonard .
NATURE REVIEWS GENETICS, 2007, 8 (11) :835-844
[8]   Aging ROS or TOR [J].
Blagosklonny, Mikhail V. .
CELL CYCLE, 2008, 7 (21) :3344-3354
[9]   Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease [J].
Boland, Barry ;
Kumar, Asok ;
Lee, Sooyeon ;
Platt, Frances M. ;
Wegiel, Jerzy ;
Yu, W. Haung ;
Nixon, Ralph A. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (27) :6926-6937
[10]   Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression [J].
Bonawitz, Nicholas D. ;
Chatenay-Lapointe, Marc ;
Pan, Yong ;
Shadel, Gerald S. .
CELL METABOLISM, 2007, 5 (04) :265-277