Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection

被引：25

作者：

Grimaldi, R

Shindo, N

Acosta, AX

Dourado, I

Brites, C

Carvalho, OD

Brito, I

Bou-Habib, DC

Galvao-Castro, B

机构：

[1] Fiocruz MS, Ctr Pesquisas Goncalo Moniz, Lab Avancado Saude Publ, BR-40295001 Salvador, BA, Brazil

[2] Escola Bahiana Med & Saude Publ, Fdn Desenvolvimento Ciencias, Salvador, BA, Brazil

[3] Univ Fed Bahia, Inst Saude Coletiva, Salvador, BA, Brazil

[4] Univ Fed Bahia, Hosp Univ Prof Edgar Santos, Salvador, BA, Brazil

[5] Secretaria Estado Saude Sao Paulo, Hemoctr Reg Joinville, Santa Catarina, Brazil

[6] Minist Saude, Programa Nacl Controle DST AIDS, Brasilia, DF, Brazil

来源：

HUMAN GENETICS | 2002年 / 111卷 / 01期

关键词：

D O I：

10.1007/s00439-002-0747-x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated the occurrence of the CCR5Delta32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Delta32/Delta32). German descendents were 11% heterozygous and 1% Delta32/Delta32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.

引用

页码：102 / 104

页数：3

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