A new route to alpha-fluorovinylphosphonates utilizing Peterson olefination methodology

被引：46

作者：

Waschbusch, R

Carran, J

Savignac, P

机构：

[1] Heteroelements et Coord., URA CNRS 1499, Ecole Polytechnique

来源：

TETRAHEDRON | 1996年 / 52卷 / 45期

关键词：

D O I：

10.1016/0040-4020(96)00859-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several alpha-fluorovinylphosphonates (6) have been synthesised from the Peterson olefination reaction applied to both aldehydes and ketones in conjunction with alpha-lithiated-alpha-fluoro-alpha-trimethylsilylmethylphosphonate (2). The reaction with aldehydes gives mainly the E-isomer whereas reaction with ketones gives mainly the Z-isomer. We propose a closed transition state to explain the results of our study. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：14199 / 14216

页数：18

共 25 条

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