Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

被引：125

作者：

Paris, F

Perez, GI

Fuks, Z

Haimovitz-Friedman, A

Nguyen, H

Bose, M

Ilagan, A

Hunt, PA

Morgan, WF

Tilly, JL

Kolesnick, R

机构：

[1] Mem Sloan Kettering Canc Ctr, Lab Signal Transduct, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Vincent Ctr Reprod Biol,Dept Obstet & Gynecol, Boston, MA USA

[4] Cornell Univ, Coll Med, Dept Pathol, New York, NY 10021 USA

[5] Univ Maryland, Dept Radiat Oncol, Baltimore, MD 21201 USA

[6] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 09期

关键词：

D O I：

10.1038/nm0902-901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：901 / 902

页数：2

共 9 条

[1] Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation [J].

Dubrova, YE ;

Plumb, M ;

Brown, J ;

Fennelly, J ;

Bois, P ;

Goodhead, D ;

Jeffreys, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6251-6255

[2] To ERR (meiotically) is human: The genesis of human aneuploidy [J].

Hassold, T ;

Hunt, P .

NATURE REVIEWS GENETICS, 2001, 2 (04) :280-291

[3] THE MICRONUCLEUS ASSAY WITH MOUSE PERIPHERAL-BLOOD RETICULOCYTES USING ACRIDINE ORANGE-COATED SLIDES [J].

HAYASHI, M ;

MORITA, T ;

KODAMA, Y ;

SOFUNI, T ;

ISHIDATE, M .

MUTATION RESEARCH, 1990, 245 (04) :245-249

[4] The effects of radiotherapy and chemotherapy on female reproduction [J].

Meirow, D ;

Nugent, D .

HUMAN REPRODUCTION UPDATE, 2001, 7 (06) :535-543

[5] Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy [J].

Morita, Y ;

Perez, GI ;

Paris, F ;

Miranda, SR ;

Ehleiter, D ;

Haimovitz-Friedman, A ;

Fuks, Z ;

Xie, ZH ;

Reed, JC ;

Schuchman, EH ;

Kolesnick, RN ;

Tilly, JL .

NATURE MEDICINE, 2000, 6 (10) :1109-1114

[6]

Nagasawa H., 1973, Experimental Animals, V22, P119

[7] Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction [J].

Perez, GI ;

Knudson, CM ;

Leykin, L ;

Korsmeyer, SJ ;

Tilly, JL .

NATURE MEDICINE, 1997, 3 (11) :1228-1232

[8] AN AIR-DRYING METHOD FOR CHROMOSOME PREPARATIONS FROM MOUSE EGGS [J].

TARKOWSKI, AK .

CYTOGENETICS, 1966, 5 (06) :394-+

[9] Commuting the death sentence: How oocytes strive to survive [J].

Tilly, JL .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (11) :838-848

← 1 →