Toxicodynamics and long-term toxicity of the recreational drug, 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy')

被引：81

作者：

Ricaurte, GA

McCann, UD

Szabo, Z

Scheffel, U

机构：

[1] Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21224 USA

[2] Johns Hopkins Med Inst, Dept Psychiat, Baltimore, MD 21224 USA

[3] Johns Hopkins Med Inst, Dept Radiol, Baltimore, MD 21224 USA

来源：

TOXICOLOGY LETTERS | 2000年 / 112卷

关键词：

serotonin; neurotoxicity; amphetamines; PET; transporters; 3,4-methylenedioxy-methamphetamine;

D O I：

10.1016/S0378-4274(99)00216-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The recreational drug, (+/-)3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), is a potent serotonin (5-HT) neurotoxin in animals. Whether humans who use MDMA incur 5-HT neural injury is unknown. The present studies utilized positron emission tomography (PET) in conjunction with the 5-HT transporter ligand, [C-11]McN-5652 to assess the status of brain 5-HT neurons in human MDMA users. Like nonhuman primates treated with neurotoxic doses of MDMA, humans with a history of MDMA use showed lasting decrements in global brain [C-11]McN-5652 binding, with decreases in [C-11]McN-5652 binding positively correlated to the extent of previous MDMA use. These results suggest that human MDMA use results in brain 5-HT neurotoxicity. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

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