The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p

被引：65

作者：

Jay, P

BergeLefranc, JL

Marsollier, C

Mejean, C

Taviaux, S

Berta, P

机构：

[1] CTR RECH BIOCHIM MACROMOL,CNRS ERS 155,INSERM U249,F-34033 MONTPELLIER,FRANCE

[2] FAC MED MARSEILLE,INSERM U406,F-13385 MARSEILLE,FRANCE

来源：

ONCOGENE | 1997年 / 14卷 / 14期

关键词：

CYR61; immediate early gene; CCN family; mosaic protein;

D O I：

10.1038/sj.onc.1200986

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.

引用

页码：1753 / 1757

页数：5

共 33 条

[1] THE MODULAR ARCHITECTURE OF A NEW FAMILY OF GROWTH-REGULATORS RELATED TO CONNECTIVE-TISSUE GROWTH-FACTOR [J].