Solution phase combinatorial chemistry .1. Synthesis of polyazacyclophane scaffolds and tertiary amine libraries

被引：26

作者：

An, HY

Cook, PD

机构：

[1] Department of Medicinal Chemistry, Isis Pharmaceutical, Inc., Carlsbad, CA 92008

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 40期

关键词：

D O I：

10.1016/0040-4039(96)01627-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel unsymmetrical polyazacyclophane scaffolds 1-3 were efficiently synthesized in high yields by a new cyclization method followed by selective deprotection. Scaffold 2 was combinatorialized by solution phase simultaneous addition of functionalities to provide 16 pure tertiary amine libraries (total 1600 compounds). Copyright (C) 1996 Elsevier Science Ltd

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页码：7233 / 7236

页数：4

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