The role of TGFβs and Sox9 during limb chondrogenesis

被引：165

作者：

Kawakami, Yasuhiko

Rodriguez-Leon, Joaquin

Belmonte, Juan Carlos Izpisua

机构：

[1] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

[2] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain

来源：

CURRENT OPINION IN CELL BIOLOGY | 2006年 / 18卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ceb.2006.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The majority of the skeletal elements, except the flat bones of the skull, are formed by endochondral ossification, in which cartilage is replaced by bone. The formation of cartilage is a multi-step process termed chondrogenesis, during which undifferentiated mesenchymal cells condense and undergo differentiation towards chondrocytes. Notwithstanding recent advances, our knowledge of the detailed mechanisms implicated in cartilage and bone formation is still scarce. Recent genetic, cellular and biochemical studies have highlighted the importance of TGF beta signaling and the activity of the transcription factor Sox9 during the early stages of vertebrate limb chondrogenesis.

引用

收藏

页码：723 / 729

页数：7

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