A Tangled Web of Ubiquitin Chains: Breaking News in TNF-R1 Signaling

被引：70

作者：

Bianchi, Katiuscia ^{[1
]}

Meier, Pascal ^{[1
]}

机构：

[1] Inst Canc Res, Chester Beatty Labs, Breakthrough Toby Robins Breast Canc Res Ctr, London SW3 6JB, England

来源：

MOLECULAR CELL | 2009年 / 36卷 / 05期

关键词：

NF-KAPPA-B; LINEAR POLYUBIQUITIN CHAINS; CONJUGATING ENZYME; PROTEIN UBIQUITINATION; BINDING DOMAIN; CELL-SURVIVAL; ACTIVATION; NEMO; COMPLEX; ALPHA;

D O I：

10.1016/j.molcel.2009.11.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A flurry of recent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in the activation of NF-kappa B, by TNF. Here, we integrate these findings into a model for TNF-R1 signaling-and underscore the importance of individual components, including linear ubiquitin chains-which allows for the remarkable versatility of the ubiquitin system.

引用

页码：736 / 742

页数：7

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