Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)

被引：40

作者：

Ahn, Jiyoung ^{[1
,2
]}

Schumacher, Fredrick R. ^{[3
]}

Berndt, Sonja I. ^{[1
]}

Pfeiffer, Ruth ^{[1
]}

Albanes, Demetrius ^{[1
]}

Andriole, Gerald L. ^{[4
]}

Ardanaz, Eva ^{[5
,6
]}

Boeing, Heiner ^{[7
]}

Bueno-de-Mesquita, Bas ^{[8
]}

Chanock, Stephen J. ^{[1
]}

Clavel-Chapelon, Francoise ^{[9
,10
]}

Diver, W. Ryan ^{[11
]}

Feigelson, Heather Spencer ^{[11
]}

Gaziano, J. Michael ^{[12
,14
,15
]}

Giovannucci, Edward ^{[12
,14
,15
]}

Haiman, Christopher A. ^{[3
]}

Henderson, Brian E. ^{[3
]}

Hoover, Robert N. ^{[1
]}

Kolonel, Laurence N. ^{[16
]}

Kraft, Peter ^{[13
]}

Ma, Jing ^{[12
,14
,15
]}

Le Marchand, Loic ^{[16
]}

Overvad, Kim ^{[17
]}

Palli, Domenico ^{[18
]}

Stattin, Paer ^{[19
]}

Stampfer, Meir ^{[12
,14
,15
]}

Stram, Daniel O. ^{[3
]}

Thomas, Gilles ^{[1
]}

Thun, Michael J. ^{[11
]}

Travis, Ruth C. ^{[20
]}

Trichopoulos, Dimitrios ^{[12
,14
,15
]}

Virtamo, Jarmo ^{[21
]}

Weinstein, Stephanie J. ^{[1
]}

Yeager, Meredith ^{[1
]}

Kaaks, Rudolf ^{[22
]}

Hunter, David J. ^{[13
]}

Hayes, Richard B. ^{[1
,2
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[2] NYU, Sch Med, Dept Environm Med, Div Epidemiol, New York, NY 10016 USA

[3] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[4] Washington Univ, Sch Med, Div Urol Surg, St Louis, MO USA

[5] Publ Hlth Inst Navarra, Pamplona, Spain

[6] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[7] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[8] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[9] INSERM, ERI 20, Paris EA 4045, Paris, France

[10] Inst Gustave Roussy, F-94805 Villejuif, France

[11] Amer Canc Soc, Dept Epidemiol & Surveillance Res, Atlanta, GA 30303 USA

[12] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[13] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Dept Epidemiol, Boston, MA 02115 USA

[14] Harvard Univ, Sch Med, Boston, MA 02115 USA

[15] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[16] Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA

[17] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol & Cardiol, Aalborg, Denmark

[18] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[19] Umea Univ, Umea, Sweden

[20] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[21] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, FIN-00300 Helsinki, Finland

[22] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

来源：

HUMAN MOLECULAR GENETICS | 2009年 / 18卷 / 19期

关键词：

ESTROGEN-RECEPTOR-ALPHA; SERUM ANDROGENS; RISK; GENE; POLYMORPHISMS; ASSOCIATION;

D O I：

10.1093/hmg/ddp302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Twin studies suggest a heritable component to circulating sex steroid hormones and sex hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort Consortium, 874 SNPs in 37 candidate genes in the sex steroid hormone pathway were examined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-androstanediol-glucuronide (N = 4767) and 17 beta-estradiol (N = 2014) in Caucasian men. rs1799941 in SHBG is highly significantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous studies, and testosterone (P = 7.54 x 10(-15)), with mean difference of 26.9 and 14.3%, respectively, comparing wild-type to homozygous variant carriers. Further noteworthy novel findings were observed between SNPs in ESR1 with testosterone levels (rs722208, mean difference = 8.8%, P = 7.37 x 10(-6)) and SRD5A2 with 3 alpha-androstanediol-glucuronide (rs2208532, mean difference = 11.8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones.

引用

页码：3749 / 3757

页数：9

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