CD44: From adhesion molecules to signalling regulators

被引：1890

作者：

Ponta, H

Sherman, L

Herrlich, PA

机构：

[1] Forschungszentrum Karlsruhe, Inst Genet & Toxikol, D-76021 Karlsruhe, Germany

[2] Oregon Hlth & Sci Univ, Oregon natl Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 01期

关键词：

D O I：

10.1038/nrm1004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell-adhesion molecules, once believed to function primarily in tethering cells to extracellular ligands, are now recognized as having broader functions in cellular signalling cascades, The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes - not only by establishing specific transmembrane complexes, but also by organizing signalling cascades through association with the actin cytoskeleton. CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation.

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页码：33 / 45

页数：13

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