Overexpression of receptor of advanced glycation end products hypersensitizes cells for amyloid beta peptide-induced cell death

被引：18

作者：

Hadding, A ^{[1
]}

Kaltschmidt, B ^{[1
]}

Kaltschmidt, C ^{[1
]}

机构：

[1] Univ Witten Herdecke, Inst Neurobiochem, D-58448 Witten, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1691卷 / 01期

关键词：

amyloid beta peptide; hemagglutinin; RAGE;

D O I：

10.1016/j.bbamcr.2004.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Receptor of advanced glycation end products (RAGE) was identified as one of the receptors for amyloid beta peptide (Abeta). There is evidence for controversial functions of RAGE such as a mediator of cell death or differentiation. in this report, we demonstrate that RAGE mediates Abeta toxicity. Transient transfection of RAGE already induced cell death. For farther analysis, stable clones of hemagglutinin (HA)tagged RAGE were selected. Analysis of cellular localization of HA-tagged RAGE protein revealed, in addition to the expected cell surface expression, a novel intracellular localization. Stable RAGE-expressing cells were hypersensitive to nanomolar amounts of Abeta. Only cells expressing RAGE at the cell surface showed hypersensitivity to Abeta. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：67 / 72

页数：6

共 18 条

[1]

Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612

[2]

Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice [J].

Goova, MT ;

Li, J ;

Kislinger, T ;

Qu, W ;

Lu, Y ;

Bucciarelli, LG ;

Nowygrod, S ;

Wolf, BM ;

Caliste, X ;

Yan, SF ;

Stern, DM ;

Schmidt, AM .

AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (02) :513-525

[3]

An apoptosis-inducing isoform of Neu differentiation factor (NDF) identified using a novel screen for dominant, apoptosis-inducing genes [J].

Grimm, S ;

Leder, P .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (06) :1137-1142

[4]

THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) IS A CELLULAR-BINDING SITE FOR AMPHOTERIN - MEDIATION OF NEURITE OUTGROWTH AND COEXPRESSION OF RAGE AND AMPHOTERIN IN THE DEVELOPING NERVOUS-SYSTEM [J].

HORI, O ;

BRETT, J ;

SLATTERY, T ;

CAO, R ;

ZHANG, JH ;

CHEN, JX ;

NAGASHIMA, M ;

LUNDH, ER ;

VIJAY, S ;

NITECKI, D ;

MORSER, J ;

STERN, D ;

SCHMIDT, AM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :25752-25761

[5]

Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways [J].

Huttunen, HJ ;

Fages, C ;

Rauvala, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (28) :19919-19924

[6]

Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation [J].

Huttunen, HJ ;

Kuja-Panula, J ;

Rauvala, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (41) :38635-38646

[7]

Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for advanced glycation end products (RAGE) activation [J].

Huttunen, HJ ;

Kuja-Panula, J ;

Sorci, G ;

Agneletti, AL ;

Donato, R ;

Rauvala, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (51) :40096-40105

[8]

Transcription factor NF-kappa B is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease [J].

Kaltschmidt, B ;

Uherek, M ;

Volk, B ;

Baeuerle, PA ;

Kaltschmidt, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2642-2647

[9]

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis [J].

Kaltschmidt, B ;

Uherek, M ;

Wellmann, H ;

Volk, B ;

Kaltschmidt, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :9409-9414

[10]

THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

← 1 2 →