Expression of IL-6 in the ischemic penumbra

被引：75

作者：

Block, F ^{[1
]}

Peters, M ^{[1
]}

Nolden-Koch, M ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Dept Neurol, D-52057 Aachen, Germany

来源：

NEUROREPORT | 2000年 / 11卷 / 05期

关键词：

cerebral ischemia; IL-6; microglia; neuron; rat;

D O I：

10.1097/00001756-200004070-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the expression of IL-6 within the ischemic penumbra at various time points after transient (3 h) middle cerebral occlusion (MCA-O) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodies against GFAP, OX 42, IL-6 and Nissl-staining. Glial activation within the penumbra started on day one after ischemia and persisted up to day 14. Expression of IL-6 was not present in sham-operated controls. One day after MCA-O there were several IL-6-positive cells in the penumbra. This expression of IL-6 increased on day 3 and remained elevated up to day 14. According to the shape of the IL-6-positive cells they seem to be microglia and neurons. The present results demonstrate a longlasting expression of IL-6 in the ischemic penumbra. NeuroReport 11:963-967 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：963 / 967

页数：5

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