Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage

被引：15

作者：

Rajakrishnan, V

Viswanathan, P

Rajasekharan, KN

Menon, VP ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem, Ctr Micronutrient Res, Annamalainagar Nagar 608002, India

[2] Annamalai Univ, Dept Pathol, RMMC, Annamalainagar Nagar 608002, India

[3] Univ Kerala, Dept Chem, Trivandrum 695581, Kerala, India

来源：

PHYTOTHERAPY RESEARCH | 1999年 / 13卷 / 07期

关键词：

curcumin; neuroprotective; hypolipidaemic; antioxidative;

D O I：

10.1002/(SICI)1099-1573(199911)13:7<571::AID-PTR494>3.0.CO;2-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

In the present study, curcumin from Curcuma longa was screened for neuroprotective activity using ethanol as a model of brain injury. Oral administration of curcumin to rats caused a significant reversal in lipid peroxidation, brain lipids and produced enhancement of glutathione, a non-enzymic antioxidant in ethanol intoxicated rats, revealing that the antioxidative and hypolipidaemic action of curcumin is responsible for its protective role against ethanol induced brain injury. Copyright (C) 1999 John Wiley & Sons, Ltd.

引用

页码：571 / 574

页数：4

共 34 条

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CEREBELLAR DEGENERATION ASSOCIATED WITH CHRONIC ALCOHOLISM [J].