Synthesis of New 4-(tert-Octyl)phenol Derivatives and Their Anticancer Activity against Human Prostate and Lung Cancer Cell Lines

被引：3

作者：

Che, Haiyan ^{[1
]}

Fang, Yuanying ^{[1
]}

Gurung, Santosh K. ^{[1
]}

Luo, Jun ^{[1
]}

Yoon, Deok Hyo ^{[2
]}

Sung, Gi-Ho ^{[3
]}

Kim, Tae Woong ^{[2
]}

Park, Haeil ^{[1
]}

机构：

[1] Kangwon Natl Univ, Coll Pharm, Chunchon 200701, South Korea

[2] Kangwon Natl Univ, Coll Nat Sci Biochem, Chunchon 200701, South Korea

[3] Rural Dev Adm, Suwon 441707, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2014年 / 35卷 / 07期

关键词：

Cordyceps militaris; Militarin; 4-(tert-Octyl)phenol derivatives; D-Mannitol substructure; Anticancer activity; CORDYCEPS-MILITARIS; 3'-DEOXYADENOSINE;

D O I：

10.5012/bkcs.2014.35.7.2038

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

4-(tert-Octyl)phenol derivative bearing, the D-mannitol substructure (6a, 6b, 7) were prepared from D-mannitol and evaluated their anticancer activity against human lung (A549) and prostate (Lncap, Du145, PC3) cancer cell lines. Among derivatives tested, the bis(tert-octyl)phenoxy compound 7 exhibited strongest proliferation inhibitory activities against human cancer cell lines tested, especially high sensitivity to human Du145 prostate cancer cells (IC50 = 7.3 mu M).

引用

页码：2038 / 2042

页数：5

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