Endocannabinoids protect cerebral cortical neurons from in vitro ischemia in rats

被引：151

作者：

Sinor, AD ^{[1
]}

Irvin, SM ^{[1
]}

Greenberg, DA ^{[1
]}

机构：

[1] Buck Ctr Res Aging, Novato, CA 94948 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 278卷 / 03期

关键词：

cannabinoid; anandamide; 2-arachidonylglycerol; ischemia; hypoxia; cell culture;

D O I：

10.1016/S0304-3940(99)00922-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The endogenous cannabinoids (endocannabinoids) anandamide and 2-arachidonylglycerol increased cell viability in cerebral cortical neuron cultures subjected to 8 h of hypoxia and glucose deprivation, This effect was observed at nanomolar concentrations, was reproduced by a non-hydrolyzable analog of anandamide, and was unaltered by CB1 or CB2 cannabinoid receptor antagonists. Like synthetic cannabinoids, endocannabinoids can protect neurons from hypoxic injury, and may represent endogenous neuroprotective molecules in cerebral ischemia. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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页码：157 / 160

页数：4

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