Giving Uridine and/or Docosahexaenoic Acid Orally to Rat Dams during Gestation and Nursing Increases Synaptic Elements in Brains of Weanling Pups

被引：31

作者：

Cansev, Mehmet ^{[1
,2
]}

Marzloff, George ^{[1
]}

Sakamoto, Toshimasa ^{[1
,3
]}

Ulus, Ismail H. ^{[1
,2
]}

Wurtman, Richard J. ^{[1
]}

机构：

[1] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[2] Uludag Univ, Sch Med, Dept Pharmacol & Clin Pharmacol, Bursa, Turkey

[3] Kobe Gakuin Univ, Dept Rehabil Med, Kobe, Hyogo 65121, Japan

来源：

DEVELOPMENTAL NEUROSCIENCE | 2009年 / 31卷 / 03期

关键词：

Development; Docosahexaenoic acid; Uridine; Membrane phosphatides; Dendritic spines; Synaptic proteins; Synaptogenesis; Infant nutrition; POLYUNSATURATED FATTY-ACIDS; NUCLEOSIDE TRANSPORTER FAMILY; CDP-CHOLINE; ARACHIDONIC-ACID; DENDRITIC SPINES; BREAST-MILK; PHEOCHROMOCYTOMA CELLS; NEURITE OUTGROWTH; FETAL-DEVELOPMENT; DIETARY CHOLINE;

D O I：

10.1159/000193394

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developing neurons synthesize substantial quantities of membrane phospholipids in producing new synapses. We investigated the effects of maternal uridine (as uridine-5'-monophosphate) and docosahexaenoic acid supplementation on pups' brain phospholipids, synaptic proteins and dendritic spine densities. Dams consumed neither, 1 or both compounds for 10 days before parturition and 20 days while nursing. By day 21, brains of weanlings receiving both exhibited significant increases in membrane phosphatides, various pre- and postsynaptic proteins (synapsin-1, mGluR1, PSD-95), and in hippocampal dendritic spine densities. Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：181 / 192

页数：12

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