Long-Term Follow-Up Trial of Oral Rifampin-Cotrimoxazole Combination versus Intravenous Cloxacillin in Treatment of Chronic Staphylococcal Osteomyelitis

被引：62

作者：

Euba, G. ^{[1
]}

Murillo, O. ^{[1
]}

Fernandez-Sabe, N. ^{[1
]}

Mascaro, J. ^{[1
]}

Cabo, J. ^{[2
]}

Perez, A. ^{[2
]}

Tubau, F. ^{[3
]}

Verdaguer, R. ^{[3
]}

Gudiol, F. ^{[1
]}

Ariza, J. ^{[1
]}

机构：

[1] Hosp Univ Bellvitge, Dept Infect Dis, IDIBELL, Barcelona 08907, Spain

[2] Hosp Univ Bellvitge, Dept Orthoped Surg, IDIBELL, Barcelona 08907, Spain

[3] Hosp Univ Bellvitge, Dept Microbiol, IDIBELL, Barcelona 08907, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期

关键词：

INFECTED ORTHOPEDIC IMPLANTS; TRIMETHOPRIM-SULFAMETHOXAZOLE; AUREUS; OFLOXACIN; INVIVO; ANTIBIOTICS; INVITRO; VANCOMYCIN; EFFICACY; AGENTS;

D O I：

10.1128/AAC.01504-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Oral therapies alternative to fluoroquinolones against staphylococcal chronic osteomyelitis have not been evaluated in comparative studies. Consecutive nonaxial Staphylococcus aureus chronic osteomyelitis cases were included in a comparative trial after debridement. Fifty patients were randomized: group A (n = 22) was treated with cloxacillin for 6 weeks intravenously plus 2 weeks orally (p.o.), and group B (n = 28) was treated with rifampin-cotrimoxazole for 8 weeks p.o. During follow-up (10 years), five relapses occurred: two (10%) in group A and three (11%) in group B. Foreign-body maintenance was associated with relapse (P = 0.016). Oral rifampin-cotrimoxazole treatment showed outcomes comparable to those for intravenous cloxacillin treatment.

引用

页码：2672 / 2676

页数：5

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