Mercury transport and resistance

被引:39
作者
Brown, NL
Shih, YC
Leang, C
Glendinning, KJ
Hobman, JL
Wilson, JR
机构
[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
[2] Univ Massachusetts, Dept Microbiol, Amherst, MA 01003 USA
[3] Univ Liverpool, Dept Med Microbiol & GU Med, Liverpool L69 3GA, Merseyside, England
[4] Natl Inst Med Res, Prot Struct Div, London NW7 1AA, England
关键词
heavy metal; ion transport; membrane protein; mercuric ion resistance;
D O I
10.1042/BST0300715
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Resistance to mercuric ions in bacteria is conferred by, mercuric reductase, which reduces Hg(II) to Hg(0) in the cytoplasmic compartment. Specific mercuric ion transport systems exist to take up Hg(11) salts and deliver them to the active site of the reductase. This short review discusses the role of transport proteins in resistance and the mechanism of transfer of Hg(11) between the mercury-resistance proteins.
引用
收藏
页码:715 / 718
页数:4
相关论文
共 16 条
[1]   BACTERIAL-RESISTANCE TO MERCURY - REDUCTIO AD ABSURDUM [J].
BROWN, NL .
TRENDS IN BIOCHEMICAL SCIENCES, 1985, 10 (10) :400-403
[2]  
BROWN NL, 1991, J CELL BIOCHEM, V46, P106
[3]  
BROWN NL, 1984, FLAVINS FLAVOPROTEIN, P165
[4]   THE SEQUENCE OF THE MER OPERON OF PMER327/419 AND TRANSPOSON ENDS OF PMER327/419, PMER330 AND PMER05 [J].
HOBMAN, J ;
KHOLODII, G ;
NIKIFOROV, V ;
RITCHIE, DA ;
STRIKE, P ;
YURIEVA, O .
GENE, 1994, 146 (01) :73-78
[5]  
Hobman JL, 1997, MET IONS BIOL SYST, V34, P527
[6]  
Hobman JL, 2000, ENVIRONMENTAL MICROBE-METAL INTERACTIONS, P177
[7]   Transposon Tn21, flagship of the floating genome [J].
Liebert, CA ;
Hall, RM ;
Summers, AO .
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1999, 63 (03) :507-+
[8]   Bacterial detoxification of Hg(II) and organomercurials [J].
Miller, SM .
ESSAYS IN BIOCHEMISTRY, VOL 34, 1999, 1999, 34 :17-30
[9]   MUTAGENESIS OF THE N-TERMINAL AND C-TERMINAL CYSTEINE PAIRS OF TN501 MERCURIC ION REDUCTASE - CONSEQUENCES FOR BACTERIAL DETOXIFICATION OF MERCURIALS [J].
MOORE, MJ ;
WALSH, CT .
BIOCHEMISTRY, 1989, 28 (03) :1183-1194
[10]   THE ROLE OF CYSTEINE RESIDUES IN THE TRANSPORT OF MERCURIC IONS BY THE TN501 MERT AND MERP MERCURY-RESISTANCE PROTEINS [J].
MORBY, AP ;
HOBMAN, JL ;
BROWN, NL .
MOLECULAR MICROBIOLOGY, 1995, 17 (01) :25-35