Impact of polymorphisms in xeno(endo)biotic metabolism on pattern and frequency of p53 mutations in bladder cancer

被引：17

作者：

Martone, T

Vineis, P

Malaveille, C

Terracini, B

机构：

[1] Dipartimento Sci Biomed & Oncol Umana, Unit Canc Epidemiol, I-10126 Turin, Italy

[2] Ist Ric Canc, Candiolo, Italy

[3] Int Agcy Res Canc, F-69372 Lyon, France

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2000年 / 462卷 / 2-3期

关键词：

p53; mutations; metabolic polymorphisms; bladder cancer;

D O I：

10.1016/S1383-5742(00)00013-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have analyzed the tumor biopsies of 45 patients with bladder cancer for p53 mutations by direct sequencing. In addition to N-acetyltransferase-2 (NAT2) and GSTM1 allelisms, which were examined previously, we have analyzed the genetic polymorphisms of GSTT1, GSTP1. COMT. NQO1, TS-SULT and MPO in buffy coat DNA using PCR-based methods. All subjects were interviewed through a questionnaire on smoking, dietary habits and other risk factors. No specific pattern was evident for p53 mutations. Eight out of ten mutations occurred in grade 3 tumors. All p53 mutations occurred in subjects with the COMT mutated allele (p = 0.03). The prevalence of cases with p53 mutations was 3.5-fold higher in subjects with wild type than in those with variant GSTP1 alleles (p = 0.03). The other polymorphisms investigated were not associated with p53 mutations. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：303 / 309

页数：7

共 39 条

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