Drug delivery systems and materials for wound healing applications

被引：607

作者：

Saghazadeh, Saghi ^{[1
,2
]}

Rinoldi, Chiara ^{[1
,2
,3
]}

Schot, Maik ^{[1
,2
,4
]}

Kashaf, Sara Saheb ^{[1
,2
,5
]}

Sharifi, Fatemeh ^{[1
,2
,6
]}

Jalilian, Elmira ^{[1
,2
,13
]}

Nuutila, Kristo ^{[7
]}

Giatsidis, Giorgio ^{[7
]}

Mostafalu, Pooria ^{[1
,2
]}

Derakhshandeh, Hossein ^{[8
]}

Yue, Kan ^{[1
,2
]}

Swieszkowski, Wojciech ^{[3
]}

Memic, Adnan ^{[9
]}

Tamayol, Ali ^{[1
,2
,8
]}

Khademhosseini, Ali ^{[1
,2
,9
,10
,11
,12
,14
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Biomat Innovat Res Ctr, Boston, MA 02139 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Warsaw Univ Technol, Fac Mat Sci & Engn, Mat Design Div, PL-02507 Warsaw, Poland

[4] Univ Twente, Dept Dev BioEngn, MIRA Inst Biomed Technol & Tech Med, Enschede, Netherlands

[5] Univ Chicago, Pritzker Sch Med, Med Scientist Training Program, Chicago, IL 60637 USA

[6] Sharif Univ Technol, Sch Mech Engn, Tehran, Iran

[7] Brigham & Womens Hosp, Div Plast Surg, Boston, MA 02115 USA

[8] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68508 USA

[9] King Abdulaziz Univ, Ctr Nanotechnol, Jeddah 21569, Saudi Arabia

[10] Univ Calif Los Angeles, Calif NanoSyst Inst CNSI, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA

[11] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[12] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90095 USA

[13] UCL, UCL Inst Ophthalmol, London EC1V 9E1, England

[14] King Abdulaziz Univ, Dept Phys, Jeddah 21569, Saudi Arabia

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 127卷

基金：

美国国家卫生研究院;

关键词：

Wound healing; Drug delivery; Transdermal delivery; Microtechnologies; Nanotechnologies; VACUUM-ASSISTED CLOSURE; EPIDERMAL-GROWTH-FACTOR; MESOPOROUS SILICA NANOPARTICLES; MESENCHYMAL STEM-CELLS; CONTROLLED-RELEASE; POLYMERIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; ALGINATE MICROSPHERES; RESPONSIVE POLYMERS; GOLD NANOPARTICLES;

D O I：

10.1016/j.addr.2018.04.008

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：138 / 166

页数：29

共 266 条

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