Left Cardiac Sympathetic Denervation in Patients with Heart Failure: a New Indication for an Old Intervention?

被引：12

作者：

De Ferrari, Gaetano M. ^{[1
,2
]}

Schwartz, Peter J. ^{[3
,4
,5
,6
,7
,8
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Dept Cardiol, Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Cardiovasc Clin Res Ctr, Pavia, Italy

[3] IRCCS Ist Auxol Italiano, Ctr Cardiac Arrhythmias Genet Origin, I-20135 Milan, Italy

[4] IRCCS Ist Auxol Italiano, Lab Cardiovasc Genet, I-20135 Milan, Italy

[5] Univ Pavia, Dept Mol Med, I-27100 Pavia, Italy

[6] Univ Cape Town, Dept Med, Cardiovasc Genet Lab, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, South Africa

[7] Univ Stellenbosch, Dept Internal Med, ZA-7600 Stellenbosch, South Africa

[8] King Saud Univ, Coll Med, Dept Family & Community Med, Chair Sudden Death, Riyadh 11461, Saudi Arabia

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2014年 / 7卷 / 03期

关键词：

Sympathetic denervation; Autonomic nervous system; Heart failure; Life-threatening arrhythmias; Vagus nerve; ACUTE MYOCARDIAL-ISCHEMIA; LONG-QT SYNDROME; CONSCIOUS DOGS; VAGAL-STIMULATION; NERVOUS-SYSTEM; SUDDEN-DEATH; ANTIADRENERGIC INTERVENTIONS; VENTRICULAR-TACHYCARDIA; LEFT STELLECTOMY; ANGINA-PECTORIS;

D O I：

10.1007/s12265-014-9541-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Heart failure (HF) is characterized by an autonomic imbalance with withdrawal of vagal activity and increased sympathetic activity. Novel non-pharmacological approaches to HF aimed at increasing vagal activity are being proposed. Left cardiac sympathetic denervation (LCSD) has been shown to modify favorably the outcome of several disorders characterized by life-threatening arrhythmias triggered by increased sympathetic activity. The present manuscript discusses the rationale and the limited experimental and clinical experience suggesting a potential role for LCSD in the treatment of patients with advanced heart failure. Possible future clinical applications of LCSD may include HF patients who are intolerant to beta-adrenergic blockade, HF patients who have frequent implantable cardioverter-defibrillator shocks, and HF patients in countries where the likelihood of receiving a device is limited, but the capability to perform a one in a lifetime procedure is present.

引用

页码：338 / 346

页数：9

共 61 条

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