Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

被引：208

作者：

Ahluwalia, Bani ^{[1
,2
]}

Moraes, Luiza ^{[1
]}

Magnusson, Maria K. ^{[1
]}

Ohman, Lena ^{[1
,3
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Microbiol & Immunol, Gothenburg, Sweden

[2] Calmino Grp AB, Res Unit, Gothenburg, Sweden

[3] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Internal Med & Clin Nutr, Gothenburg, Sweden

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 2018年 / 53卷 / 04期

关键词：

IBD; immunopathogenesis; Crohn's disease; ulcerative colitis; chronic inflammation; dysregulated immune response; dysbiosis; biological therapies; INNATE LYMPHOID-CELLS; REGULATORY T-CELL; ACTIVE CROHNS-DISEASE; TOLL-LIKE RECEPTOR-9; ANTI-TNF THERAPY; ULCERATIVE-COLITIS; MAINTENANCE THERAPY; DOUBLE-BLIND; DENDRITIC CELLS; INTESTINAL INFLAMMATION;

D O I：

10.1080/00365521.2018.1447597

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of reach and, therefore, treatment is far from ideal. Nevertheless, components involved in IBD pathogenesis including environmental, genetic, microbial, and immunological factors are continuously being investigated and the improved knowledge contributes to the development of new therapies. In this article we review the aspects of the immunopathogenesis of IBD, with focus on mucosal immunity, and discuss mechanisms of action for current and emerging biological therapies.

引用

页码：379 / 389

页数：11

共 147 条

[1]

Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease [J].

Adams, DH ;

Eksteen, B .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (03) :244-251

[2]

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad [J].

Ahluwalia, Bani ;

Magnusson, Maria K. ;

Ohman, Lena .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2017, 52 (11) :1185-1193

[3]

Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial [J].

Allez, Matthieu ;

Skolnick, Brett E. ;

Wisniewska-Jarosinska, Maria ;

Petryka, Robert ;

Overgaard, Rune Viig .

GUT, 2017, 66 (11) :1918-1925

[4]

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 [J].

Anderson, Carl A. ;

Boucher, Gabrielle ;

Lees, Charlie W. ;

Franke, Andre ;

D'Amato, Mauro ;

Taylor, Kent D. ;

Lee, James C. ;

Goyette, Philippe ;

Imielinski, Marcin ;

Latiano, Anna ;

Lagace, Caroline ;

Scott, Regan ;

Amininejad, Leila ;

Bumpstead, Suzannah ;

Baidoo, Leonard ;

Baldassano, Robert N. ;

Barclay, Murray ;

Bayless, Theodore M. ;

Brand, Stephan ;

Buening, Carsten ;

Colombel, Jean-Frederic ;

Denson, Lee A. ;

De Vos, Martine ;

Dubinsky, Marla ;

Edwards, Cathryn ;

Ellinghaus, David ;

Fehrmann, Rudolf S. N. ;

Floyd, James A. B. ;

Florin, Timothy ;

Franchimont, Denis ;

Franke, Lude ;

Georges, Michel ;

Glas, Juergen ;

Glazer, Nicole L. ;

Guthery, Stephen L. ;

Haritunians, Talin ;

Hayward, Nicholas K. ;

Hugot, Jean-Pierre ;

Jobin, Gilles ;

Laukens, Debby ;

Lawrance, Ian ;

Lemann, Marc ;

Levine, Arie ;

Libioulle, Cecile ;

Louis, Edouard ;

McGovern, Dermot P. ;

Milla, Monica ;

Montgomery, Grant W. ;

Morley, Katherine I. ;

Mowat, Craig .

NATURE GENETICS, 2011, 43 (03) :246-U94

[5]

Tumor necrosis factor inhibitors: Clinical implications of their different immunogenicity profiles [J].

Anderson, PJ .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2005, 34 (05) :19-22

[6]

Severe Ulcerative Colitis After Rituximab Therapy [J].

Ardelean, Daniela S. ;

Gonska, Tanja ;

Wires, Shannon ;

Cutz, Ernest ;

Griffiths, Anne ;

Harvey, Elizabeth ;

Tse, Shirley M. L. ;

Benseler, Susanne M. .

PEDIATRICS, 2010, 126 (01) :E243-E246

[7]

Interleukin-10 therapy - Review of a new approach [J].

Asadullah, K ;

Sterry, W ;

Volk, HD .

PHARMACOLOGICAL REVIEWS, 2003, 55 (02) :241-269

[8]

Atreya R., 2010, INFLAMM BOWEL DIS, P52

[9]

The molecular regulation of Janus kinase (JAK) activation [J].

Babon, Jeffrey J. ;

Lucet, Isabelle S. ;

Murphy, James M. ;

Nicola, Nicos A. ;

Varghese, Leila N. .

BIOCHEMICAL JOURNAL, 2014, 462 :1-13

[10]

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region [J].

Barrett, Jeffrey C. ;

Lee, James C. ;

Lees, Charles W. ;

Prescott, Natalie J. ;

Anderson, Carl A. ;

Phillips, Anne ;

Wesley, Emma ;

Parnell, Kirstie ;

Zhang, Hu ;

Drummond, Hazel ;

Nimmo, Elaine R. ;

Massey, Dunecan ;

Blaszczyk, Kasia ;

Elliott, Timothy ;

Cotterill, Lynn ;

Dallal, Helen ;

Lobo, Alan J. ;

Mowat, Craig ;

Sanderson, Jeremy D. ;

Jewell, Derek P. ;

Newman, William G. ;

Edwards, Cathryn ;

Ahmad, Tariq ;

Mansfield, John C. ;

Satsangi, Jack ;

Parkes, Miles ;

Mathew, Christopher G. ;

Donnelly, Peter ;

Peltonen, Leena ;

Blackwell, Jenefer M. ;

Bramon, Elvira ;

Brown, Matthew A. ;

Casas, Juan P. ;

Corvin, Aiden ;

Craddock, Nicholas ;

Deloukas, Panos ;

Duncanson, Audrey ;

Jankowski, Janusz ;

Markus, Hugh S. ;

McCarthy, Mark I. ;

Palmer, Colin N. A. ;

Plomin, Robert ;

Rautanen, Anna ;

Sawcer, Stephen J. ;

Samani, Nilesh ;

Trembath, Richard C. ;

Viswanathan, Ananth C. ;

Wood, Nicholas ;

Spencer, Chris C. A. ;

Bellenguez, Celine .

NATURE GENETICS, 2009, 41 (12) :1330-U99

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