Phosphatidylinositol 3-kinase related kinases

被引：56

作者：

Abraham, RT

机构：

[1] Department of Immunology, Mayo Clinic/Foundation, Rochester, MN 55905

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(96)80132-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies in yeast, flies and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase, These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical manifestations ranging from immunodeficiency to cancer.

引用

收藏

页码：412 / 418

页数：7

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