Seven-transmembrane receptors

被引：2028

作者：

Pierce, KL

Premont, RT

Lefkowitz, RJ

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 09期

关键词：

D O I：

10.1038/nrm908

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.

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收藏

页码：639 / 650

页数：12

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