Photoactivated DNA cleavage via charge transfer promoted N2 release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

被引：44

作者：

Maurer, TD

Kraft, BJ

Lato, SM

Ellington, AD

Zaleski, JM ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem & Biochem, Bloomington, IN 47405 USA

[2] Univ Texas, Dept Mol Biol, Austin, TX 78712 USA

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 01期

关键词：

D O I：

10.1039/a908005h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Visible wavelength ligand-to-metal (LMCT) activated N-2 release from tris(3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III) produces localized ligand radical intermediates capable of cleaving DNA and represents a new chemical approach to photonuclease design for biological applications.

引用

收藏

页码：69 / 70

页数：2

相关论文

共 13 条

[1]

ADAMSON J, 1969, CHEM COMMUN, P221

[2] NEW CLASS OF DNA-CLEAVING AGENTS BASED ON TRIMETHYLENEMETHANE [J].

BREGANT, TM ;

GROPPE, J ;

LITTLE, RD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (08) :3635-3636

[3] Photodynamic therapy [J].

Dougherty, TJ ;

Gomer, CJ ;

Henderson, BW ;

Jori, G ;

Kessel, D ;

Korbelik, M ;

Moan, J ;

Peng, Q .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (12) :889-905

[4] REVISED STRUCTURES FOR THE KINAMYCIN ANTIBIOTICS - 5-DIAZOBENZO[B]FLUORENES RATHER THAN BENZO[B]CARBAZOLE CYANAMIDES [J].

GOULD, SJ ;

TAMAYO, N ;

MELVILLE, CR ;

CONE, MC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (05) :2207-2208

[5] DNA strand cleavage by tumor-inhibiting antibiotic 6-diazo-5-oxo-L-norleucine [J].

Hiramoto, K ;

Fujino, T ;

Kikugawa, K .

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS, 1996, 360 (02) :95-100

[6]

Horvath O., 1993, CHARGE TRANSFER PHOT, P207

[7] SPECTROSCOPIC STUDIES OF THE ELECTRONIC-STRUCTURE OF IRON(III) TRIS(CATECHOLATES) [J].

KARPISHIN, TB ;

GEBHARD, MS ;

SOLOMON, EI ;

RAYMOND, KN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (08) :2977-2984

[8]

KOBYLECKI RJ, 1976, ADV HETEROCYCLIC CHE, V19

[9] DNA cleavage by photoexcited diazoarenes [J].

Maiya, BG ;

Ramana, CV ;

Arounaguiri, S ;

Nagarajan, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (16) :2141-2144

[10] STABILITIES OF THE IRON(III) CHELATES OF 1,2-DIMETHYL-3-HYDROXY-4-PYRIDINONE AND RELATED LIGANDS [J].

MOTEKAITIS, RJ ;

MARTELL, AE .

INORGANICA CHIMICA ACTA, 1991, 183 (01) :71-80