Dendritic cell biology, dysfunction and immunotherapy in gastrointestinal cancers

被引：10

作者：

Aloysius, M. M.

Takhar, A.

Robins, A.

Eremin, O.

机构：

[1] Univ Nottingham Hosp, Queens Med Ctr, Sect Surg, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Queens Med Ctr, Dept Immunol, Nottingham NG7 2UH, England

[3] Lincoln Cty Hosp, United Lincolnshire NHS Trust, Res & Dev, Lincoln, England

来源：

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2006年 / 4卷 / 04期

关键词：

dendritic cells; gastrointestinal cancers; immunotherapy; cytotoxic T lymphocytes; T helper cells;

D O I：

10.1016/S1479-666X(06)80061-2

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Gastrointestinal (GI) cancers make up a significant proportion of newly diagnosed malignant disease. The five-year survival for these GI cancers is poor. Anti-cancer host defences are thought to play a role in these cancers, albeit they are suboptimal. Novel immunotherapies are being introduced to treat such patients. This review describes basic cell biology of dendritic cells, as they are thought to play a key role in generating effective anti-tumour responses. Dendritic cell dysfunction in patients with various cancers is documented and immunotherapy using dendritic cells in a range of GI cancers is described and discussed.

引用

页码：195 / 210

页数：16

共 163 条

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Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].