Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu)

被引：201

作者：

Lee, JB

Hayashi, K

Hashimoto, M

Nakano, T

Hayashi, T

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Sch Med, Toyama 9300194, Japan

[3] Riken Vitamin Co Ltd, Chiyoda Ku, Tokyo 1018370, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 09期

关键词：

fucoidan; Undaria pinnatitida; sporophyll; antiviral activity; Mekabu;

D O I：

10.1248/cpb.52.1091

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural characterization and antiviral activities of fucoidan from sporophyll of Undaria pinnatifida (Mekabu) was examined. The fucoidan was composed of fucose and galactose with an approximately ratio of 1.0 : 1.1. Degree of substitution of sulfate was 0.72 and its apparent molecular weight was 9000. Methylation analyses showed that fucoidan had various sugar linkages, and revealed that the fucoidan might have complicated structure. This fucoidan showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), HSV-2, and human cytomegalovirus.

引用

页码：1091 / 1094

页数：4

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