Naive human alpha beta T cells respond to membrane-associated components of malaria-infected erythrocytes by proliferation and production of interferon-gamma

被引:28
作者
Dick, S [1 ]
Waterfall, M [1 ]
Currie, J [1 ]
Maddy, A [1 ]
Riley, E [1 ]
机构
[1] UNIV EDINBURGH,INST CELL ANIM & POPULAT BIOL,ASHWORTH LABS,DIV BIOL SCI,EDINBURGH EH9 3JT,MIDLOTHIAN,SCOTLAND
基金
英国惠康基金;
关键词
D O I
10.1046/j.1365-2567.1996.d01-661.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Crude extracts of Plasmodium falciparum schizont-infected erythrocytes (PfSE) induce polyclonal activation of peripheral blood T lymphocytes from naive (malaria unexposed) humans. We demonstrate that the active component of PfSE is membrane bound, soluble in sodium dodecyl sulphate (SDS) and partially heat stable, but distinct from the tumour necrosis factor (TNF)-inducing, exoantigen-like activity of schizont extracts. Malaria pigment induces little or no T-cell activation. The responding cells are predominately CD4(+), CD45RO(+), T-cell receptor (TCR)alpha beta(+). Contrary to previous reports, expansion of the TCR gamma delta(+) subset was observed in cells from only one of eight donors. Proliferating cells secrete interferon-gamma (IFN-gamma) and release large amounts of soluble interleukin-2R (sIL-2R) into the culture supernatant but produce no detectable interleukin-4 (IL-4), a phenotype typical of the T-helper (Th)1 subset of CD4(+) T cells. We propose that these activated T cells may initiate the inflammatory response to malaria infection in non-immunes and may contribute to the pathology of the disease.
引用
收藏
页码:412 / 420
页数:9
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