Synthesis and preliminary biological evaluation of truncated zoanthenol analogues

被引：24

作者：

Hirai, G

Oguri, H ^{[1
]}

Hayashi, M

Koyama, K

Koizumi, Y

Moharram, SM

Hirama, M

机构：

[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan

[2] Kitasato Inst Life Sci, Tokyo 1088641, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2004.02.064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Zoanthamines are a family of marine alkaloids that have complex heptacyclic structures and are reported to be interleukin-6 modulators. While the structure of zoanthamines, especially the ABC-ring portion, is similar to that of steroids, the CDEFG-ring portion, composed of aminoacetal and lactone core, is a unique structural element. In this report, we designed and synthesized ABC-ring 6 and CDEFG-ring 7, which are truncated analogues of the northern and southern hemispheres of zoanthenol 5, respectively, and which incorporate all of the functionality of each hemisphere. A preliminary SAR study suggested that the hydrochloride of the CEFG-ring portion is an active pharmacophore for suppressing the growth of interleukin-6-dependent MH60 cells. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2647 / 2651

页数：5

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