The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats

被引：53

作者：

ChojnackaWojcik, E ^{[1
]}

Tatarczynska, E ^{[1
]}

Pilc, A ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,PL-31343 KRAKOW,POLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 319卷 / 2-3期

关键词：

metabotropic glutamate receptor; S-4C3H-PG ((S)-4-carbonyl-3-hydroxyphenylglycine); MSOP ((RS)-alpha-methylserine-O-phosphate); drinking conflict test; intrahippocampal injection;

D O I：

10.1016/S0014-2999(96)00941-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity, after their intrahippocampal administration of (S)-4-carboxy-3-hydroxyphenyl-glycine (S-4C3H-PG), (RS)-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE) and (RS)-alpha-methylserine-O-phosphate (MSOP), the antagonists of the I, the II and the III group of metabotropic glutamate receptors (mGlu receptors), respectively. The results indicate that S-4C3H-PG and MSOP produced a dose-dependent anticonflict effect in rats, which was unrelated to a reduced perception of the stimulus or to an increased thirst drive. The hippocampus may be one of the neuroanatomical sites of the anxiolytic-like effects of both mGlu receptor antagonists.

引用

页码：153 / 156

页数：4

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