Heterogeneity of papillomaviruses

被引：20

作者：

Myers, G

Lu, H

Calef, C

Leitner, T

机构：

[1] Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos

来源：

SEMINARS IN CANCER BIOLOGY | 1996年 / 7卷 / 06期

关键词：

papillomavirus; parsimony; phenotype; transformation; zoonosis;

D O I：

10.1006/scbi.1996.0044

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The classification of the papillomaviral sequence into types is satisfactory for many purposes, but the resulting catalog does not accurately depict the extent of diversification of this family of viruses. Phylogenetic and mutational analyses reveal that some viral forms are much more ancient than other forms. Episodic evolutionary events and zoonotic transmission may have contributed to the overall pattern. sequences Convergent evolution appears to be the best explanation for warranted. the scattered occurrence across the family tree of viruses with high oncogenic risk. We look for the determinants of this risk among the less conserved residues of the viral E6 and E7 transforming proteins. (C) 1997 Academic Press Ltd.

引用

页码：349 / 358

页数：10

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