Risk Factors Associated with Subclinical Human Infection with Avian Influenza A (H5N1) Virus-Cambodia, 2006

被引:76
作者
Vong, Sirenda [1 ]
Ly, Sowath [1 ]
Van Kerkhove, Maria D. [1 ]
Achenbach, Jenna [4 ]
Holl, Davun [2 ]
Buchy, Philippe [1 ]
Sorn, San [2 ]
Seng, Heng [3 ]
Uyeki, Timothy M. [4 ]
Sok, Touch [3 ]
Katz, Jacqueline M. [4 ]
机构
[1] Inst Pasteur, Phnom Penh, Cambodia
[2] Minist Agr Forestry & Fisheries, Phnom Penh, Cambodia
[3] Minist Hlth, Phnom Penh, Cambodia
[4] Ctr Dis Control & Prevent, Atlanta, GA USA
关键词
TRANSMISSION; OUTBREAK; ANTIBODY; WORKERS; SITES;
D O I
10.1086/599208
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. We conducted investigations in 2 villages in Cambodia where outbreaks of influenza H5N1 occurred among humans and poultry to determine the frequency of and risk factors for H5N1 virus transmission. Methods. During May 2006, similar to 7 weeks after outbreaks of influenza H5N1 among poultry occurred, villagers living near households of 2 patients with influenza H5N1 were interviewed about potential H5N1 exposures and had blood samples obtained for H5N1 serological testing by microneutralization assay. A seropositive result was defined as an influenza H5N1 neutralizing antibody titer of >= 1:80, with confirmation by Western blot assay. A case-control study was conducted to identify risk factors for influenza H5N1 virus infection. Control subjects, who had seronegative results of tests, were matched with H5N1-seropositive persons by village residence, households with an influenza H5N1-infected poultry flock, sex, and age. Results. Seven (1.0%) of 674 villagers tested seropositive for influenza H5N1 antibodies and did not report severe illness; 6 (85.7%) were male. The 7 H5N1-seropositive persons, all of whom were aged <= 18 years, were younger than participants who tested seronegative for H5N1 antibodies (median age, 12.0 years vs. 27.4 years; P = .03) and were more likely than were the 24 control subjects to report bathing or swimming in household ponds (71.4% vs. 20.8%; matched odds ratio, 11.3; P = .03). Conclusions. Avian-to-human transmission of influenza H5N1 virus remains low, despite extensive poultry contact. Exposure to a potentially contaminated environment was a risk factor for human infection.
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收藏
页码:1744 / 1752
页数:9
相关论文
共 35 条
  • [1] Abdel-Ghafar AN, 2008, NEW ENGL J MED, V358, P261, DOI 10.1056/NEJMra0707279
  • [2] [Anonymous], 2008, Wkly Epidemiol Rec, V83, P359
  • [3] [Anonymous], Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO
  • [4] Influenza outbreak among health care workers in an avian influenza (H5N1) - Endemic setting
    Apisarnthanarak, Anucha
    Mundy, Linda M.
    [J]. CLINICAL INFECTIOUS DISEASES, 2006, 43 (11) : 1493 - 1494
  • [5] Areechokchai Darin, 2006, MMWR Suppl, V55, P3
  • [6] Influenza outbreak in a correctional facility
    Awofeso, N
    Fennell, M
    Waliuzzaman, Z
    O'Connor, C
    Pittam, D
    Boonwaat, L
    de Kantzow, S
    Rawlinson, WD
    [J]. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 2001, 25 (05) : 443 - 446
  • [7] Current concepts - Avian influenza A (H5N1) infection in humans
    Beigel, H
    Farrar, H
    Han, AM
    Hayden, FG
    Hyer, R
    de Jong, MD
    Lochindarat, S
    Tien, NTK
    Hien, NT
    Hien, TT
    Nicoll, A
    Touch, S
    Yuen, KY
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) : 1374 - 1385
  • [8] Neuraminidase antibodies and H5N1:: Geographic-dependent influenza epidemiology could determine cross-protection against emerging strains
    Bermejo-Martin, Jesus F.
    Kelvin, David J.
    Guan, Yi
    Chen, Honglin
    Perez-Brena, Pilar
    Casas, Inmaculada
    Arranz, Eduardo
    de Lejarazu, Raul O.
    [J]. PLOS MEDICINE, 2007, 4 (06): : 1130 - 1131
  • [9] Persistence of H5 and H7 avian influenza viruses in water
    Brown, Justin D.
    Swayne, David E.
    Cooper, Robert J.
    Burns, Rachel E.
    Stallknecht, David E.
    [J]. AVIAN DISEASES, 2007, 51 (01) : 285 - 289
  • [10] Influenza A/H5N1 virus infection in humans in Cambodia
    Buchy, Philippe
    Mardy, Sek
    Vong, Sirenda
    Toyoda, Tetsuya
    Aubin, Jean-Thierry
    Miller, Megge
    Touch, Sok
    Sovann, Ly
    Dufourcq, Jean-Baptiste
    Richner, Beat
    Van Tu, Phan
    Tien, Nguyen Thi Kim
    Lim, Wilina
    Peiris, J. S. Malik
    Van der Werf, Sylvie
    [J]. JOURNAL OF CLINICAL VIROLOGY, 2007, 39 (03) : 164 - 168