Nanopore analytics: sensing of single molecules

被引：997

作者：

Howorka, Stefan ^{[1
]}

Siwy, Zuzanna ^{[2
]}

机构：

[1] UCL, Dept Chem, Inst Struct Mol Biol, London WC1H 0AJ, England

[2] Univ Calif Irvine, Sch Phys Sci, Irvine, CA 92697 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 08期

基金：

美国国家科学基金会; 英国工程与自然科学研究理事会;

关键词：

SOLID-STATE NANOPORE; DNA HAIRPIN MOLECULES; ION-CURRENT RECTIFICATION; TRANSVERSE ELECTRONIC TRANSPORT; PROTEIN-LIGAND INTERACTIONS; SEQUENCE-SPECIFIC DETECTION; TUNABLE NANOFLUIDIC DIODE; CHANNEL-FORMING PEPTIDES; LIPID-BILAYER MEMBRANE; NANOMETER-SCALE PORE;

D O I：

10.1039/b813796j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

引用

页码：2360 / 2384

页数：25

共 319 条

[1] Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules [J].

Akeson, M ;

Branton, D ;

Kasianowicz, JJ ;

Brandin, E ;

Deamer, DW .

BIOPHYSICAL JOURNAL, 1999, 77 (06) :3227-3233

[2] Imaging α-hemolysin with molecular dynamics:: Ionic conductance, osmotic permeability, and the electrostatic potential map [J].

Aksimentiev, A ;

Schulten, K .

BIOPHYSICAL JOURNAL, 2005, 88 (06) :3745-3761

[3] Microscopic kinetics of DNA translocation through synthetic nanopores [J].

Aksimentiev, A ;

Heng, JB ;

Timp, G ;

Schulten, K .

BIOPHYSICAL JOURNAL, 2004, 87 (03) :2086-2097

[4] Salting out the ionic selectivity of a wide channel: The asymmetry of OmpF [J].

Alcaraz, A ;

Nestorovich, EM ;

Aguilella-Arzo, M ;

Aguilella, VM ;

Bezrukov, SM .

BIOPHYSICAL JOURNAL, 2004, 87 (02) :943-957

[5] A pH-tunable nanofluidic diode:: Electrochemical rectification in a reconstituted single ion channel [J].

Alcaraz, Antonio ;

Ramirez, Patricio ;

Garcia-Gimenez, Elena ;

Lopez, M. Lidon ;

Andrio, Andreu ;

Aguilella, Vicente M. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (42) :21205-21209

[6]

Alcaraz A, 2009, BIOPHYS J, V96, P56, DOI [10.1016/j.bpj.2008.09.024, 10.1016/j.hpj.2008.09.024]

[7]

ALI M, 2008, NANOTECHNOLOGY, V19

[8]

ALI M, 2008, NANOTECHNOLOGY, V19

[9] A pH-Tunable Nanofluidic Diode with a Broad Range of Rectifying Properties [J].

Ali, Mubarak ;

Ramirez, Patricio ;

Mafe, Salvador ;

Neumann, Reinhard ;

Ensinger, Wolfgang .

ACS NANO, 2009, 3 (03) :603-608

[10] Biosensing and Supramolecular Bioconjugation in Single Conical Polymer Nanochannels. Facile Incorporation of Biorecognition Elements into Nanoconfined Geometries [J].

Ali, Mubarak ;

Yameen, Basit ;

Neumann, Reinhard ;

Ensinger, Wolfgang ;

Knoll, Wolfgang ;

Azzaroni, Omar .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (48) :16351-16357

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