Epigenetic Mechanisms Facilitating Oligodendrocyte Development, Maturation, and Aging

被引：62

作者：

Copray, Sjef ^{[1
]}

Huynh, Jimmy Long ^{[2
]}

Sher, Falak ^{[1
]}

Casaccia-Bonnefil, Patrizia ^{[2
]}

Boddeke, Erik ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, NL-9713 AV Groningen, Netherlands

[2] Mt Sinai Sch Med, Dept Neurosci & Genet & Genom, New York, NY USA

来源：

GLIA | 2009年 / 57卷 / 15期

关键词：

histone modification; oligodendrocyte differentiation; microRNA; multiple sclerosis; MYELIN BASIC-PROTEIN; HISTONE DEACETYLASE ACTIVITY; NEURAL STEM-CELLS; MULTIPLE-SCLEROSIS; TRANSCRIPTIONAL CONTROL; GENE-EXPRESSION; PROGENITOR DIFFERENTIATION; NEURONAL DIFFERENTIATION; PRECURSOR CELLS; SPINAL-CORD;

D O I：

10.1002/glia.20881

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The process of oligodendrocyte differentiation is regulated by a dynamic interaction between a genetic and an epigenetic program. Recent studies, addressing nucleosomal histone modifications have considerably increased our knowledge regarding epigenetic regulation of gene expression during oligodendrocyte development and aging. These results have generated new hypotheses regarding the mechanisms underlying the decreased efficiency of endogenous remyelination in response to demyelinating injuries with increasing age. In this review, we present an overview of the epigenetic mechanisms regulating gene expression at specific stages of oligodendrocyte differentiation and maturation as well as the changes that occur with aging. (C) 2009 Wiley-Liss, Inc.

引用

页码：1579 / 1587

页数：9

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