Therapeutic modulation of Notch signalling - are we there yet?

被引：422

作者：

Andersson, Emma R. ^{[1
]}

Lendahl, Urban ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 05期

基金：

瑞典研究理事会;

关键词：

GAMMA-SECRETASE INHIBITOR; CAUSES SPONDYLOCOSTAL DYSOSTOSIS; PULMONARY ARTERIAL-HYPERTENSION; MESOPOROUS SILICA NANOPARTICLES; ACUTE LYMPHOBLASTIC-LEUKEMIA; BETA-SELECTION CHECKPOINT; AORTIC-VALVE DISEASE; PHASE-I; TUMOR-SUPPRESSOR; PROTEOLYTIC CLEAVAGE;

D O I：

10.1038/nrd4252

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

The Notch signalling pathway is evolutionarily conserved and is crucial for the development and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases, such as T cell leukaemia, Alagille syndrome and a stroke and dementia syndrome known as CADASIL, and so strategies to therapeutically modulate Notch signalling are of interest. Clinical trials of Notch pathway inhibitors in patients with solid tumours have been reported, and several approaches are under preclinical evaluation. In this Review, we focus on aspects of the pathway that are amenable to therapeutic intervention, diseases that could be targeted and the various Notch pathway modulation strategies that are currently being explored.

引用

页码：359 / 380

页数：22

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