A new benzoangelicin with strong photobiological activity

被引：32

作者：

Santana, L

Uriarte, E ^{[1
]}

Dalla Via, L

Gia, O

机构：

[1] Univ Santiago de Compostela, Quim Farmaceut Lab, Fac Farm, Santiago, Spain

[2] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(99)00640-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4-6 exhibited cutaneous phototoxicity. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：135 / 137

页数：3

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