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Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects

被引：150
作者：
Leonard, JV
Schapira, AHV
机构：
[1] Royal Free & Univ Coll Med Sch, Univ Dept Clin Neurosci, London NW3 2PF, England
[2] UCL, Neurol Inst, London, England
[3] Inst Child Hlth, Biochem Endocrine & Metab Unit, London, England
来源：
LANCET | 2000年 / 355卷 / 9201期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1016/S0140-6736(99)05226-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The first part of this review (Lancet 2000; 355: 299) covered primary disorders of mitochondrial DNA (mtDNA). This section will cover nuclear-encoded defects of the oxidative phosphorylation (OXPHOS) system, including mtDNA mutations that are secondary to nuclear gene mutations and nuclear gene defects responsible for secondary OXPHOS deficiency (panel). The latter group of diseases are predominantly neurodegenerative. The mitochondrion's role in apoptosis and its contribution to the pathogenesis of neurodegenerative diseases are also covered.
引用
收藏
页码：389 / 394
页数：6
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