Gestational Hyperandrogenism in Developmental Programming

被引：77

作者：

Hakim, Christopher ^{[1
]}

Padmanabhan, Vasantha ^{[2
]}

Vyas, Arpita K. ^{[1
,3
]}

机构：

[1] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA

[2] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Pediat, Permian Basin Campus, Odessa, TX 79763 USA

来源：

ENDOCRINOLOGY | 2017年 / 158卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CONGENITAL ADRENAL-HYPERPLASIA; PRENATAL TESTOSTERONE EXCESS; POLYCYSTIC-OVARY-SYNDROME; REPRODUCTIVE NEUROENDOCRINE FUNCTION; INTRAUTERINE GROWTH-RETARDATION; ENDOCRINE-DISRUPTING CHEMICALS; AUTISM SPECTRUM DISORDER; FEMALE RHESUS-MONKEYS; ANDROGEN EXCESS; BISPHENOL-A;

D O I：

10.1210/en.2016-1801

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Androgen excess (hyperandrogenism) is a common endocrine disorder affecting women of reproductive age. The potential causes of androgen excess in women include polycystic ovary syndrome, congenital adrenal hyperplasia (CAH), adrenal tumors, and racial disparity among many others. During pregnancy, luteoma, placental aromatase deficiency, and fetal CAH are additional causes of gestational hyperandrogenism. The present report reviews the various phenotypes of hyperandrogenism during pregnancy and its origin, pathophysiology, and the effect of hyperandrogenism on the fetal developmental trajectory and offspring consequences.

引用

页码：199 / 212

页数：14

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