Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture

被引：105

作者：

Kozuki, Y ^{[1
]}

Miura, Y ^{[1
]}

Yagasaki, K ^{[1
]}

机构：

[1] Tokyo Noko Univ, Dept Appl Biol Sci, Fuchu, Tokyo 1838509, Japan

来源：

CANCER LETTERS | 2000年 / 151卷 / 01期

关键词：

hepatoma; antioxidant; carotenoid; invasion; hypoxanthine-xanthine oxidase system;

D O I：

10.1016/S0304-3835(99)00418-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The effects of carotenoids - alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, zeaxanthin, lutein, canthaxanthin, astaxanthin - on the invasion of rat ascites hepatoma AH109A cells were investigated by co-culturing the hepatoma cells with rat mesentery-derived mesothelial cells (M-cells). All the carotenoids examined inhibited AH109A invasion in a dose-dependent manner up to 5 mu M. Cancer cells previously cultured with hypoxanthine (HX) and xanthine oxidase (XO) showed a highly invasive activity. Carotenoids, 5 mu M of beta-carotene and astaxanthin, suppressed this reactive oxygen species-potentiated invasive capacity by simultaneously treating AH109A cells with the carotenoids, HX and XO. These results suggest that the antioxidative property of these carotenoids may be involved in their anti-invasive action. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 115

页数：5

共 16 条

[1]

AKEDO H, 1986, CANCER RES, V46, P2416

[2]

Tumor cell-endothelial cell interactions: Evidence for roles for lipoxygenase products of arachidonic acid in metastasis [J].

Damtew, B ;

Spagnuolo, PJ .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1997, 56 (04) :295-300

[3]

LIOTTA LA, 1983, LAB INVEST, V49, P636

[4]

Eicosanoids as mediators of linoleic acid-stimulated invasion and type IV collagenase production by a metastatic human breast cancer cell line [J].

Liu, XH ;

Connolly, JM ;

Rose, DP .

CLINICAL & EXPERIMENTAL METASTASIS, 1996, 14 (02) :145-152

[5]

Lomnitski L, 1997, INT J VITAM NUTR RES, V67, P407

[6]

THE INTERACTION BETWEEN BETA-CAROTENE AND LIPOXYGENASE IN PLANT AND ANIMAL SYSTEMS [J].

LOMNITSKI, L ;

BARNATAN, R ;

SKLAN, D ;

GROSSMAN, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1167 (03) :331-338

[7]

Inhibitory effect of serum from rats administered with coffee on the proliferation and invasion of rat ascites hepatoma cells [J].

Miura, Y ;

Furuse, T ;

Yagasaki, K .

CYTOTECHNOLOGY, 1997, 25 (1-3) :221-225

[8]

Assay systems for screening food components that have anti-proliferative and anti-invasive activity to rat ascites hepatoma cells: In vitro and ex vivo effects of green tea extract [J].

Miura, Y ;

Shiomi, H ;

Sakai, F ;

Yagasaki, K .

CYTOTECHNOLOGY, 1997, 23 (1-3) :127-132

[9]

CAN DIETARY BETA-CAROTENE MATERIALLY REDUCE HUMAN CANCER RATES [J].

PETO, R ;

DOLL, R ;

BUCKLEY, JD ;

SPORN, MB .

NATURE, 1981, 290 (5803) :201-208

[10]

Identification of arachidonic acid pathways required for the invasive and metastatic activity of malignant tumor cells [J].

Reich, R ;

Martin, GR .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1996, 51 (01) :1-17

← 1 2 →